A Nutrition & Exercise Prehabilitation Intervention on Inflammatory Biomarkers in AI Cancer Patients

Summary

The purpose of this study is to assess the feasibility of a prehab intervention among American Indian (AI) patients diagnosed with cancer and measure inflammatory biomarkers to evaluate the preliminary impact of the trial intervention. The central hypothesis is that this community-informed prehab intervention will demonstrate feasibility, patient acceptability, and modulation of host and tumor-microenvironment inflammatory biomarkers. Aim 1: Implement the prehab translational clinical trial for AI patients with cancer scheduled for treatment. Aim 2 Measure host and tumor-microenvironment (TME) biomarkers using paired serum and tissue samples to compare baseline and post-intervention levels of expression. Serum markers include CRP, IL-6, IL-10, TNFa, IGF-1, VEGF, complete blood count (CBC) with differential, comprehensive metabolic panel (CMP), and prealbumin. Tissue markers include Ki67, insulin receptor, TNFa, NFKB, NOS2, and cleaved caspase 3. Aim 3: (optional exploratory aim): Assess differential expression of inflammatory genes in the TME using tumor tissue samples to compare baseline and post-intervention levels of expression. This will be done with a panel that analyzes inflammatory genes only.

Eligibility

Inclusion Criteria:

* Age 18-80 years
* Diagnosed with cancer of any kind
* Scheduled at least 3 weeks out from first treatment
* Receiving care at San Carlos Apache Healthcare Corporation (SCAHC)
* Able to eat walnuts
* Able to do moderate-intensity exercise

Exclusion Criteria:

* Digestive tract disease that would restrict diet modifications
* Allergy to the foods intended for the nutrition intervention
* Uncontrolled cardiac disease or other contraindications to moderate-intensity exercise

Conditions2

Locations1 site

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