Continuous Glucose Monitoring in People With Diabetes on Dialysis

Summary

Continuous glucose monitoring is a sensor, which monitors glucose levels continuously throughout the day. In people with diabetes, especially those treated with insulin, this sensor helps guide the amount of treatment (such as insulin) required to maintain glucose within target. In dialysis, the glucose levels and insulin needs can change a lot because of the kidney failure and dialysis treatments. The goal of this observational study is to describe the changes in glucose during and in between dialysis sessions over two weeks by using continuous glucose monitoring. The study will also explore whether there is a relationship between the trend of the glucose and fluid level changes during and in between dialysis treatments. Also, the study will assess whether there is a relationship between glucose levels and several long-term outcomes, such as admissions to the hospital, for up to five years.

Eligibility

Inclusion criteria:

* Age: ≥18 years (no upper age limit)
* People with insulin-treated diabetes who receive NHS funded continuous glucose monitoring as part of their routine clinical care
* Diabetes duration \> 6 months
* People with end-stage renal disease established on dialysis (maintenance haemodialysis or peritoneal dialysis)
* Ability to give informed consent

Exclusion criteria:

* Participation in other competing studies/clinical trials as determined by the study investigator
* Serious illness or events with life expectancy \< 3 months or other significant illness which, in the opinion of the study clinician, precludes involvement

Conditions3

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