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Treating Loneliness In The Older Adult With Depression With tDCS

RECRUITINGN/ASponsored by Guangzhou Psychiatric Hospital
Actively Recruiting
PhaseN/A
SponsorGuangzhou Psychiatric Hospital
Started2024-10-29
Est. completion2026-10-20
Eligibility
Age60 Years – 80 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06658795

Summary

High loneliness is prevalent among older adults and is a significant risk factor for major depression and low recovery rates in patients. Current interventions for loneliness are limited. Previous research has demonstrated a link between loneliness, negative social emotions, and reduced resting-state functional connectivity in the lateral prefrontal cortex (LPFC) and the default mode network (DMN). Transcranial direct current stimulation (tDCS) has shown promise in enhancing emotional regulation and connectivity, potentially alleviating loneliness in older adults with depression.

Eligibility

Age: 60 Years – 80 YearsHealthy volunteers accepted
Inclusion Criteria:

* High loneliness (UCLA Loneliness Scale \> 43).
* Diagnosis of major depressive disorder confirmed by the Structured Clinical Interview for DSM-5 Disorders.
* absence of suicidal ideation (Hamilton Depression Scale item 3 score ≤ 1).

Exclusion Criteria:

* Severe neurological diseases.
* Bipolar disorder, schizophrenia, addiction, or impulse control disorders.
* Contraindications for tDCS or MRI (e.g., metal implants).
* Presence of suicidal ideation.

Conditions3

DepressionLonelinessMajor Depressive Disorder

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