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Utilizing Long-read Sequencing to Investigate the EGFR Landscape of EGFR Positive Lung Cancer Patients

RECRUITINGSponsored by Our Lady of the Lake Hospital
Actively Recruiting
SponsorOur Lady of the Lake Hospital
Started2025-01-01
Est. completion2025-12-31
Eligibility
Age18 Years – 100 Years
SexFEMALE
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06659458

Summary

EGFR gene mutations are some of the most commonly occurring mutations in non-small cell lung cancer. Investigators have developed a DNA instability model that estimates a risk score to assess the likelihood of an individual acquiring a cancer-linked mutation. The aim of this study is to collect blood from both those diagnosed with EGFR positive lung cancer and healthy individuals, evaluate their gene sequence surrounding the EGFR landscape and use the cancer positive and healthy sequences to validate the risk assessment model, which may one day be used to provide insight on susceptibility of getting EGFR positive lung cancer or potentially other cancer types.

Eligibility

Age: 18 Years – 100 YearsSex: FEMALEHealthy volunteers accepted
Inclusion Criteria:

* 18-100 years old
* Biologically born female
* Diagnosed with EGFR positive lung cancer (Arm 1-Cancer group)
* No cancer diagnosis (Arm 2-health control)

Exclusion Criteria:

* less than 18 years of age
* Biologically born male
* Incarcerated at the time of participation

Conditions4

CancerEGFR Exon 19 Deletion MutationLung CancerLung Cancer - Non Small Cell

Locations1 site

Our Lady of the Lake Regional Medical Center
Baton Rouge, Louisiana, 70808

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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