Evaluation of Exercise Testing and Physical Activity in Children and Adolescents Living With Inherited Arrhythmias

Summary

The goal of this observational study is to evaluate exercise testing and daily physical activity in children and adolescents who are diagnosed with an inherited arrhythmia. The main question it aims to answer is: Does maximum heart rate during controlled exercise tolerance testing accurately reflect maximum heart rate and peak exercise levels during free living daily physical activity in children and adolescents diagnosed with an inherited arrhythmia? Participants will: * Complete routine exercise tolerance testing * Record daily physical activity and exercise over two weeks, while wearing an activity and heart rate monitor and digit diary. * Complete a physical activity questionnaire at the end of two weeks.

Eligibility

Inclusion Criteria:

Affected cohort

* Male and female children
* Aged 6-16 years
* Diagnosed with long QT syndrome or catecholaminergic polymorphic ventricular tachycardia
* Treated with beta-blocker and/or sodium channel blockade
* Able to complete a treadmill ETT

Healthy cohort

* Male and female children
* Aged 6-16 years
* Siblings of affected children (gene negative)
* Undergoing IAS screening
* Able to complete a treadmill ETT

Exclusion Criteria:

* Children aged less than 6 years
* Adults, 17 years of age and above
* Unable to run on an exercise treadmill due to physical limitations.
* Individuals unable to speak or understand English, due to no translation service available.
* Pregnancy

Conditions4

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