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Does Co-administration of Lactate Affect Postprandial Nutrient Absorption and Fat Disposition?

RECRUITINGN/ASponsored by University of Aarhus
Actively Recruiting
PhaseN/A
SponsorUniversity of Aarhus
Started2024-08-22
Est. completion2026-01
Eligibility
Age50 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06668714

Summary

Aim To investigate the effects of oral lactate administration on nutrient absorption and substrate utilization in individuals with pre-diabetes. Hypothesis The addition of lactate to a meal improves postprandial lipemia and reduces lipid storage in ectopic tissues through delayed absorption and faster removal of circulating lipids from circulation.

Eligibility

Age: 50 Years+Healthy volunteers accepted
Inclusion Criteria:

* 50+ years
* Written and oral consent
* HbA1c 39-47 mmol/L

Exclusion Criteria:

* Medicine with an impact on blood glucose and glucose metabolism.
* Newly started medicine (\<3 months prior to the inclusion time)
* Medicine changes (\<3 months prior to the inclusion time and planned changes during the trial)
* Affected screening blood sample as evaluated by PI
* Hba1c \> 47
* Allergy to paracetamol
* Doesn't speak or understand Danish
* Special diets

The eight healthy individuals will be included by the same criteria except for not having pre-diabetes

Conditions3

DiabetesMetabolic SyndromePre Diabetes

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