Myocardial Perfusion Quantification With SPECT Using Multi-Pinhole Collimator Compared to Photon-Counting Coronary CTA

Summary

This prospective study aims to compare functional abnormalities detected using myocardial perfusion SPECT imaging (MPI SPECT) with the extent and severity of anatomical findings on coronary computed tomography angiography (coronary CTA). Additionally, the investigators aim to enhance the diagnostic value of MPI SPECT by quantifying myocardial blood flow and utilizing myocardial flow reserve calculated from dynamic SPECT images. 50 patients with suspected coronary artery disease are anticipated to be enrolled. Pharmacological stress and rest-phase dynamic and static MPI SPECT following an additional coronary CTA scan are to be performed. The obtained multimodality imaging data (functional and anatomical parameters) are planned to be compared and subjected to statistical analysis. The results of this study are expected to improve risk assessment for patients with moderate cardiovascular risk and enhance the diagnostic performance of MPI SPECT.

Eligibility

Inclusion Criteria:

* suspected coronary artery disease
* referred to coronary CTA or SPECT MPI by the patient's physician
* agrees to the other imaging modality that was not indicated by their physician (coronary CTA or SPECT MPI)
* suitable for informed consent

Exclusion Criteria:

* moderate or severe aortic valve stenosis
* atrial fibrillation
* pregnancy or breastfeeding
* history of coronary artery bypass graft implantation
* history of stent implantation
* chronic renal failure (eGFR \< 30 ml/m2)
* active oncological treatment
* congenital heart disease
* left or right bundle branch block

Conditions10

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