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Early Amiodarone in Shockable Cardiac Arrest

RECRUITINGPhase 3Sponsored by Oregon Health and Science University
Actively Recruiting
PhasePhase 3
SponsorOregon Health and Science University
Started2025-01-01
Est. completion2027-12-31
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06680869

Summary

The primary objective of this pilot, pragmatic stepped-wedge cluster randomized trial is to evaluate if a modified cardiac arrest treatment algorithm calling for the administration of the initial amiodarone dose one 2-minute cycle earlier than current guidelines (during the same cycle as the initial dose of epinephrine) improves the time to amiodarone delivery in those with out-of-hospital cardiac arrest due to refractory ventricular fibrillation or ventricular tachycardia compared to usual care.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Emergency medical services (EMS)-treated non-traumatic out-of-hospital cardiac arrest
* Initial rhythm on EMS rhythm assessment of ventricular fibrillation or ventricular tachycardia
* Recurrence or persistence of ventricular fibrillation or ventricular tachycardia after one defibrillation attempt

Exclusion Criteria:

* Known allergy to amiodarone
* EMS-assessed contraindication to amiodarone
* Pre-existing "do-not-attempt-resuscitation" orders
* Inter-facility transportations
* Initial care by a non-participating EMS agency able to perform advanced life support interventions
* Pediatric patient as determined by EMS
* Prisoners
* Pregnant patients

Conditions2

Cardiac ArrestHeart Disease

Locations1 site

Oregon Health & Sciences University
Portland, Oregon, 97035
Joshua Lupton, MD, MPH503-418-6706lupton@ohsu.edu

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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