Efficacy and Influencing Factors of Deep Transcranial Magnetic Stimulation in the Treatment of OCD

Summary

This study aims to explore the efficacy and influencing of accelerated dTMS (deep Transcranial Magnetic Stimulation) treatment in patients with obsessive-compulsive disorder (OCD), and explores the potential neural mechanisms of treatment effect by magnetic resonance imaging (MRI) and electroencephalography (EEG).

Eligibility

Inclusion Criteria:

* Aged between 18 and 50, both genders are welcome.
* DSM-5 criteria for OCD.
* Y-BOCS total score ≥ 20 despite therapeutic-dose SRI treatment or completion of at least one full course of CBT. The treatment regimen must have been stable for at least 8 weeks prior to enrollment and remain unchanged throughout the study.
* More than 9 years of education.
* Right-handed.

Exclusion Criteria:

* Any additional current psychiatric comorbidity, except for obsessive- compulsive personality disorder.
* Severe obsessive symptoms prevent the completion of necessary assessments.
* Has a history of receiving ECT therapy.
* Has received rTMS or tDCS treatment within the past two months.
* Has severe physical illnesses or any physical conditions that can induce epilepsy or intracranial hypertension, including cardiovascular and respiratory diseases, among others.
* Has a past history of neurological disorders (such as epilepsy, cerebrovascular accidents, etc.) or brain injuries, or a history of brain surgery.
* Has implanted medical devices such as intracranial stents, cardiac pacemakers, coronary stents, cochlear implants, etc.
* Serious suicide risk.
* Pregnancy or nursing of an infant.

Conditions2

Browse More Trials