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A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors

RECRUITINGPhase 1/2Sponsored by Bristol-Myers Squibb
Actively Recruiting
PhasePhase 1/2
SponsorBristol-Myers Squibb
Started2025-02-17
Est. completion2029-01-04
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations7 sites
View on ClinicalTrials.gov →

NCT06697197

Summary

The purpose of this study is to test the safety and efficacy of BMS-986482 alone and as combination therapy in participants with advanced solid tumors.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* All participants must have a histologically or cytologically confirmed, advanced, unresectable/metastatic, solid malignancy measurable by RECIST v1.1, and have received, be refractory to, ineligible for, intolerant of, or refused existing therapy(ies) known to provide clinical benefit for the condition of the participant.
* Participant must be ≥ 18 years or the legal age of consent in the jurisdiction in which the study is taking place, inclusive, at the time of signing the ICF.

Exclusion Criteria:

* History of life threatening immune mediated toxicity related to prior T-cell agonist or checkpoint inhibitor therapy, except those that are unlikely to re-occur with standard countermeasures.
* Any significant acute or chronic medical illness which would interfere with study intervention or follow-up in the opinion of the investigator.
* Other protocol-defined Inclusion/Exclusion criteria apply.

Conditions2

Advanced Solid TumorsCancer

Locations7 sites

University of California, Irvine (UCI) Health - UC Irvine Medical Center
Irvine, California, 92612
Warren Chow, Site 0005626-372-7121
The Angeles Clinic and Research Institute - West Los Angeles Office
Los Angeles, California, 90025
Omid Hamid, Site 0030310-231-2121
Local Institution - 0008
Aurora, Colorado, 80045
Site 0008
John Theurer Cancer Center at Hackensack University Medical Center
Hackensack, New Jersey, 07601
Martin Gutierrez, Site 0009551-996-5863
Northwell Health/ RJ Zuckerberg Cancer Center
Lake Success, New York, 11042
Nagashree Seetharamu, Site 0007917-574-8494

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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