Differential Study of Invasive Pituitary Adenomas in the Sellar and Cavernous Sinus Regions

Summary

This study involves collecting paired tumor samples from intrasellar and cavernous sinus regions of 20 invasive pituitary tumor patients, preserving them at -80°C for quality multi-omics analysis. Proteomics and transcriptomics are employed to identify molecular differences, while imaging data (MRI/CT) assesses tumor morphology and invasion. In vitro experiments and mechanistic studies validate key findings, exploring how regional molecular differences affect tumor behavior. Data integration combines multi-omics and imaging features to uncover biomarkers and pathways associated with invasiveness and regional specificity, with statistical analysis ensuring significance and reliability.

Eligibility

Inclusion Criteria:

1. Invasive pituitary tumors involving the cavernous sinus
2. Retrospective inclusion of patients who have signed informed consent forms for the donation of biological samples and health-related information
3. Age range: 18-80 years
4. Subjects are willing to participate in this study

Exclusion Criteria:

1. Non-invasive pituitary tumors
2. Pregnant or breastfeeding
3. Other conditions deemed unsuitable for participation in this clinical trial as assessed by the physician

Conditions2

Browse More Trials