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Physical Activity and Nutrition to Halt Elevated Risk in the Pancreas Interception Center

RECRUITINGN/ASponsored by H. Lee Moffitt Cancer Center and Research Institute
Actively Recruiting
PhaseN/A
SponsorH. Lee Moffitt Cancer Center and Research Institute
Started2025-02-19
Est. completion2027-11
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06712797

Summary

The purpose of this Study is to assist in implementing a practical, easy-to-adopt lifestyle intervention that optimizes patient outcomes and minimizes pancreatic ductal adenocarcinoma (PDAC) risk.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Age 18 years or older
* Endoscopically, radiologically, or biopsy-proven pancreatic intraductal papillary mucinous neoplasm (IPMN) over 15 mm in size
* Eastern Cooperative Oncology Group (ECOG) performance status 0-2
* Ability to sign informed consent
* Ability to read and speak English or Spanish
* Body Mass Index (BMI) greater than or equal to 25 kg/m2
* Visceral obesity based on MRI quantification of visceral and subcutaneous fat; ratio of visceral to subcutaneous fat area greater than 0.4 and/or elevated cytokine, incretin or adipokine biomarkers

Exclusion Criteria:

* No diagnosis of an IPMN
* IPMN with high grade dysplasia, cancer or other high-risk features
* Screen failure for exercise safety
* Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease
* Recent fracture or acute musculoskeletal injury
* Numeric pain rating scale of 7 or more out of 10
* Myopathic or rheumatologic disease that impacts physical function

Conditions3

CancerIntraductal Papillary Mucinous NeoplasmPancreatic Ductal Adenocarcinoma

Locations1 site

Moffitt Cancer Center
Tampa, Florida, 33612
Jennifer Permuth, PhD813-745-5744Jenny.Permuth@moffitt.org

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