Efficacy and Mechanism of Augmentation of Cognitive Behavioral Therapy With Transcranial Alternating Current Stimulation(tACS) for Obsessive-Compulsive Disorder (OCD)

Summary

This study aims to evaluate the feasibility and clinical outcome of the Exposure-based Cognitive-Behavioral Therapy (CBT) concurrent with Transcranial Alternating Current Stimulation (tACS) using individualized stimulation frequency in treating obsessive-compulsive disorder (OCD) patients, and explores the potential neural mechanisms of treatment effect by magnetic resonance imaging (MRI) and electroencephalography (EEG).

Eligibility

The investigators recruited outpatient adults with OCD confirmed by the Mini-International Neuropsychiatric Interview (MINI). The following inclusion and exclusion criteria were also applied:

Inclusion Criteria:

* 18-60 years old
* With at least 9 years of education
* Y-BOCS score ≥16
* No history of serious medical, neurological illness or other psychotic disorders other than OCD (anxiety or mild to moderate depression secondary to OCD was not exclusionary)
* Medication-free or had received stable medication for at least 8 weeks before entering the study and continued the same medication throughout the study

Exclusion Criteria:

* History of serious medical, neurological illness or other psychotic disorders other than OCD
* OCD symptoms are severe, preventing the patient from completing the required assessment and examination
* Serious suicide risk
* Women who are pregnant or planning to become pregnant
* Currently taking antiepileptic medication
* Clinically significant physical illnesses or laboratory test abnormalities that have clinical significance
* Previous completion of a full course of CBT/ERP treatment

Conditions2

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