Prevention of PostAmputation Pain With Targeted Muscle Reinnervation

Summary

The goal of this study is to compare postamputation pain (phantom limb pain and residual limb pain) one year postoperatively in patients who received a lower extremity amputation (LEA) with standard nerve handling (neurectomy) versus those who received Targeted Muscle Reinnervation (TMR). Patients between 18 and 75 years old, scheduled for an LEA (transfemoral to transtibial) as a primary or secondary sequela of vascular disease, are randomized into standard neurectomy or TMR. TMR is a frequently studied surgical technique and prevents neuroma formation by rerouting a cut mixed nerve end to a functional motor nerve. The investigators hypothesize that TMR during amputation surgery will significant improve PostAmputation Pain (PAP), quality of life, participation in family life and society, and reduction of health-related costs. Participants will be asked to complete multiple online questionnaires postoperatively regarding these outcomes at five evaluation moments (at 2 weeks, and at 3, 6, 9, and 12 months).

Eligibility

Inclusion criteria

* Patients aged between 18 and 75 years old.
* Scheduled for a transtibial, through-knee, or transfemoral amputation as a primary or secondary sequela of vascular disease.

Exclusion criteria

* Insensate limbs at the level of amputation.
* Complex Regional Pain Syndrome.
* Existing neuroma or prior neuroma surgery in the affected limb.
* Undergoing radiotherapy on the affected limb.
* Cognitive impairment, or delirium at the time of consent.
* Patients who are unfit for general anesthesia.
* No nerve surgeon trained in the TMR procedure is available

Conditions5

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