Impact of Bariatric Surgery and Liraglutide on Cognitive-Behavioral Markers of Long-Term Weight Loss in Obesity

Summary

The present research project aims to study the effects of bariatric surgery and liraglutide administration (in patients already selected for one of these procedures) on two cognitive-behavioral processes partially supported by distinct brain networks: automatic approach tendencies (underpinned by the cue-reactivity network) and behavioral inhibition (underpinned by the cue-regulation network). Additionally, the investigators aim to study how these processes may be modulated by satiety. The secondary objective of the project includes identifying cognitive-behavioral markers that can predict the response to these treatments.

Eligibility

Inclusion Criteria:

* Subjects of any ethnicity, aged between 20 and 60 years.
* BMI equal to or greater than 30 kg/m².
* No history of neurological or psychiatric disorders, as confirmed through medical history and neuropsychological screening.
* Signed informed consent and willingness to comply with all study procedures.
* Patients scheduled for surgery, treatment with liraglutide, or a dietary regimen.

Exclusion Criteria:

* Previous diagnosis of significant neurological conditions (e.g., brain injury or dementia) or major psychiatric disorders.
* Current or past psychopharmacological therapy, if prolonged.
* BMI lower than 30 kg/m².
* Lack of signed informed consent.
* Severe medical conditions, including but not limited to: hypertension, significant cardiac disease, or other disorders that may compromise patient safety.
* Confirmed pregnancy through self-report and/or breastfeeding.

Conditions2

Browse More Trials