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Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults

RECRUITINGN/ASponsored by Universidade Federal do Rio de Janeiro
Actively Recruiting
PhaseN/A
SponsorUniversidade Federal do Rio de Janeiro
Started2024-12-02
Est. completion2027-03-01
Eligibility
Age50 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06733714

Summary

BACKGROUND Cognitive decline in older adults, especially those who develop Mild Cognitive Impairment and Alzheimer's Disease, currently has limited options of pharmacological treatments, with modest efficacy. Digital Cognitive Training (DCT) and Transcranial Alternating Current Stimulation (tACS) are two promising tools for cognitive remediation in this population. In this exploratory study, we investigate feasibility, tolerability and preliminary effects of the association of both interventions in older adults with cognitive complaints. METHODS Older adults with cognitive complaints are being enrolled for this study, which comprises 5 daily sessions of 30 minutes of DCT using the BrainHQ platform while simultaneously receiving theta tACS (6Hz, 1.6mA) targeting the Left Dorsolateral Prefrontal Cortex.

Eligibility

Age: 50 Years+Healthy volunteers accepted
Inclusion Criteria:

* Healthy subjects over 50 years old, with cognitive complaints

Exclusion Criteria:

* Estimated Intelligence Quotient \<80
* Dependence on psychoactive substances (DSM-V)
* Severe psychiatric or neurological disorders
* Uncorrected visual/hearing problems
* History of syncope for an unexplained reason or seizure less than a year ago
* Previous stroke
* Use of anticoagulants
* Intracranial metallic prosthesis or cardiac pacemaker
* Any contraindication to performing tACS

Conditions12

Alzheimer DiseaseAlzheimer's DiseaseBeta-AmyloidCognitive DeclineCognitive DysfunctionDementiaDementia, VascularFrontotemporal DegenerationGFAPLewy Body Disease

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