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Transcriptomics as an Aid in the Histological Diagnosis of Acute Rejection After Liver Transplantation

RECRUITINGN/ASponsored by IRCCS Azienda Ospedaliero-Universitaria di Bologna
Actively Recruiting
PhaseN/A
SponsorIRCCS Azienda Ospedaliero-Universitaria di Bologna
Started2024-10-17
Est. completion2025-05-02
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06734013

Summary

The primary objective of this exploratory study is to identify genes associated with acute rejection in liver transplant patients. To this end, a panel of acute rejection indicator genes (both humoral and cell-mediated) will be selected from results published in the literature and applied to biological material derived from biopsies. The secodnary objective is to identify genes associated with the diagnosis of humoral acute rejection and those associated with the diagnosis of cell-mediated acute rejection.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Patients with a diagnosis of post-OLT rejection prior to the visit at which they will be enrolled, with tissue available for RT-PCR investigations
* Age ≥ 18 years
* Informed consent

Exclusion Criteria:

* Age \<18 years

Conditions2

Liver DiseaseRejection; Transplant, Liver

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