Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients

Summary

The development of atherosclerosis is significantly influenced by the interplay between lipid and inflammatory factors. Endotoxemia, defined as the presence of endotoxins, particularly lipopolysaccharides (LPS) derived from Gram-negative bacteria, in the bloodstream, is closely associated with low-grade inflammation. This chronic, systemic inflammatory response does not reach the severity of acute inflammation but can contribute to the development of atherosclerosis and cardiovascular disease (CVD). Lipopolysaccharide-binding protein (LBP) is a soluble acute-phase protein that binds to bacterial LPS. Elevated levels of LBP have been linked to increased low-grade inflammation, which further exacerbates chronic inflammation and metabolic dysregulation. Dietary fiber, such as oat bran, may have a role in mitigating the effects of endotoxemia and its associated inflammation. Furthermore, dietary fiber could play a role in improving plasma lipid profiles. The present study will investigate the effect of oat bran supplementation on cardiometabolic risk markers, LBP concentrations, selected fecal bacteria, and short-chain fatty acids receptors gene expression in peripheral blood mononuclear cells in patients with coronary artery disease.

Eligibility

Inclusion Criteria:

* Patients with a history of coronary heart disease who have recently undergone coronary angioplasty

Exclusion Criteria:

* End-stage renal disease
* Inflammatory bowel syndrome (IBD),
* Recent glucocorticoid or antibiotic treatment,
* Cancer undergoing chemotherapy or radiotherapy,
* Any alteration to the treatment plan, including changes in drug type or surgical intervention

Conditions2

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