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DAANCE FOR CHEMOTHERAPY-INDUCED NEUROPATHY

RECRUITINGPhase 2Sponsored by Ohio State University Comprehensive Cancer Center
Actively Recruiting
PhasePhase 2
SponsorOhio State University Comprehensive Cancer Center
Started2025-02-19
Est. completion2029-08-15
Eligibility
Age40 Years+
Healthy vol.Accepted
Locations2 sites

Summary

Up to 80% of breast cancer survivors experience chemotherapy-induced neuropathy that impairs quality of life and increases fall risk long into survivorship, yet treatment options for neuropathy remain limited. The successful treatment will target neurophysiologic mechanisms for restoring function while addressing patient-reported symptoms and participation in treatment. Toward this end, the investigators propose to study a noninvasive, social sensorimotor intervention - Adapted Argentine Tango - which targets motor control restoration, symptom alleviation, and treatment participation in concert.

Eligibility

Age: 40 Years+Healthy volunteers accepted
Inclusion Criteria:

* Breast Cancer (BC) diagnosis of Stage I-IV including metastatic disease
* completed taxane-based chemotherapy for BC at least 3 months ago (no limit on how long ago)
* symptomatic for chemotherapy-induced neuropathy (self-report)
* postural control score that indicates potential fall-risk
* able to understand and comply with directions associated with testing and study treatments

Exclusion Criteria:

* pre-existing vestibular dysfunction
* poorly controlled diabetes (hgA1C\>=8)
* non-ambulatory (assistive and prosthetic devices allowed)
* hearing impairment resulting in less than 10% hearing bilaterally
* contraindication to participate in the experimental physical activity per the treating oncologist due to additional condition (e.g., herniated disc, unstable bone metastases)
* currently in activity-based therapy (e.g., physical therapy, occupational therapy). May enroll if still meet eligibility criteria once activity-based therapy is complete.

Conditions4

Breast CancerCancerCancer of the BreastChemotherapy-induced Neuropathy

Locations2 sites

Connecticut

1 site
Yale University
New Haven, Connecticut, 06520
Maryam Lustberg, MD, MPHmaryam.lustberg@yale.edu

Ohio

1 site
The Ohio State University
Columbus, Ohio, 43220
Lise Worthen-Chaudhari, PhD, MFA, CMES(1) + 614-293-6281lise.worthen-chaudhari@osumc.edu

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