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Forearm Immobilization in T2D

RECRUITINGN/ASponsored by Wageningen University
Actively Recruiting
PhaseN/A
SponsorWageningen University
Started2024-11-21
Est. completion2026-04-30
Eligibility
Age18 Years – 80 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06750497

Summary

The aim of the present study is to assess the impact of short-term forearm immobilization on forearm muscle glucose uptake and amino acid net balance and kinetics in individuals with T2D compared with a control group with normoglycaemia.

Eligibility

Age: 18 Years – 80 YearsHealthy volunteers accepted
Inclusion criteria

* Males and females with or without diagnosed type 2 diabetes
* Use lifestyle changes, metformin, gliclazide, or a combination thereof as oral glucose-lowering treatments for T2D
* Aged 18-80 years at the time of signing informed consent
* 18.5 ≥ BMI ≤ 35 kg·m2

Exclusion criteria

* Type 1 or a genetic form of diabetes
* Any diagnosed cardiovascular (heart) disease or high blood pressure (≥160 mmHg systolic and/or ≥100 mmHg diastolic)
* Chronic use of any prescribed or over-the-counter pharmaceuticals (excluding oral contraceptives and contraceptive devices) that interact with muscle substrate metabolism (e.g. selective serotonin reuptake inhibitors)
* Consumption of a low-carbohydrate diet
* Smoking or chewing tobacco
* Known anaemia
* Regular use of dietary protein and/or amino acid supplements (\>3 times per week)
* Currently involved in a structured progressive resistance training program (\>3 times per week)
* A personal or family history of thrombosis (clots)
* Any previous motor disorders or inborn errors in muscle and/or lipid metabolism
* History of kidney disease
* History of liver disease
* Pregnant or breastfeeding
* History of any drug or alcohol abuse in the past two years
* Claustrophobia
* Unable to give consent

Conditions3

DiabetesHealthyType 2 Diabetes

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