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The Triad of Nutrition, Intestinal Microbiota and Rheumatoid Arthritis (TASTY)

RECRUITINGN/ASponsored by Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa
Actively Recruiting
PhaseN/A
SponsorLisbon Academic Medical Center - Centro Académico de Medicina de Lisboa
Started2023-01-02
Est. completion2025-09-30
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06758817

Summary

The main goal of this trial is to investigate whether a dietary intervention based on a typical Mediterranean Diet enriched with fermented foods (MedDiet+) can impact gut microbiota and RA-related outcomes.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* RA patients (ACR/EULAR2010 criteria)
* Age \>18-years
* Disease duration \>1-year
* Active disease (DAS28 \> 2.6units)
* On stable medication for 12 weeks
* Low/medium MedDiet adherence (PREDIMED\<10)
* Willing to comply with study protocol

Exclusion Criteria:

* Prednisolone dose ≥ 7.5 mg/day
* Antibiotic therapy 4-weeks prior to baseline
* Persistent use of NSAID's
* Inflammatory or irritable bowel disease
* Celiac disease
* Chronic diarrhea
* Diabetes
* Other immune-mediated inflammatory diseases besides RA
* Major organ dysfunction
* Cancer diagnosed in the last five years
* Health conditions which may difficult participation (cognitive impairment/psychiatric disease)
* Pregnant or lactating individuals

Conditions2

ArthritisDiet Interventions

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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