The Role of Epicardial Adiposity in Heart Failure With Preserved Ejection Fraction

Summary

In this study the investigators are aiming to recruit 130 patients with heart failure with preserved ejection fraction who are obese and non-obese to undergo CT and MRI scans, as well as some other investigations including blood tests, to help investigate if having more fat around the heart leads to worse heart function in this condition. This may lead to the development of new treatments aimed at lowering fat levels around the heart and in the rest of the body, specifically to treat HFpEF.

Eligibility

Inclusion Criteria:

* Participant is willing and able to give informed consent for participation in the study.
* Aged ≥18 years old
* Diagnosed with HFpEF and diagnosis confirmed by an experienced cardiologist using the HFA-PEFF diagnostic algorithm
* Echocardiogram performed within 12 months
* Able to understand written English

Exclusion Criteria:

* LV ejection fraction \<45%
* Severe primary valvular heart disease
* HFpEF due to infiltrative cardiomyopathy (cardiac amyloidosis or sarcoidosis), genetic hypertrophic cardiomyopathy, restrictive cardiomyopathy/pericardial disease or congenital heart disease
* Known heritable, idiopathic or drug-induced pulmonary arterial hypertension
* Absolute contraindications to cardiac CT or MRI including estimated glomerular filtration rate (eGFR) ≤30ml/min/1.73m2. Patients with MRI-compatible devices are be excluded.
* Women who are pregnant

Conditions2

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