Study of the Contribution of Mutant p53/YAP Proteins to Therapy Resistance in Recurrent Head and Neck Cancer

Summary

Multicenter, non-interventional, retrospective/prospective study of a biological nature, on patients affected by head and neck tumors, for which the collection and use of tissue samples is planned for the study of the mutational profile, the transcriptional profile and the proteomic profile.

Eligibility

Inclusion Criteria:

* Age over 18
* Patients with squamous cell tumors of the oral cavity, pharynx or larynx
* Surgical patients with primary HNSCC tumors, who have not had previous tumors in other sites or adjuvant treatments prior to surgery.
* Availability of adequate material (tissue) for the planned analyses
* Availability of follow-up data for at least one year (retrospective part)
* Written informed consent (prospective part and/or, for the retrospective part, traceable patients and/or patients in follow-up and/or if necessary for the legal nature/institutional purposes of the participating centers).

Exclusion Criteria:

* Presence of distant metastases at the time of diagnosis
* Previous head and neck cancer
* Second cancer undergoing treatment or follow-up for less than 5 years

Conditions2

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