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Insights Into the Pathophysiology of Neurovascular Uncoupling in Patients with Brain Lesions.

RECRUITINGN/ASponsored by Erasme University Hospital
Actively Recruiting
PhaseN/A
SponsorErasme University Hospital
Started2025-02-17
Est. completion2026-06-01
Eligibility
Age18 Years – 90 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06797661

Summary

Neurovascular uncoupling (NVU) represents a major source of potential bias for the identification of eloquent brain regions through activation procedures in blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI). Same region shows proper pattern in glucose metabolism in victiny of brain lesions, investigated with positron emitted tomography with radiolabeled glucose (PET-FDG) This research project aims at investigating the mechanisms of NVU by using a multimodal noninvasive imaging approach in neurosurgical patients.

Eligibility

Age: 18 Years – 90 YearsHealthy volunteers accepted
Inclusion Criteria:

* patients in the study include prior imaging showing a potentially resectable intra-cerebral mass lesion. Patient has to be included before surgery, chemotherapy and radiation

Exclusion Criteria:

* previous brain surgery
* respiratory failure
* Asthma
* Claustrophobia
* Previous adverse reaction to gadovist (contrast agent)
* Pregnancy and Breath feeding
* Diabetes (type I and II)

Conditions4

AstrocytomaCancerGlioblastomaGlioma

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