Different Cycles of Neoadjuvant PD-1 Blockades + Chemotherapy for Advanced Gastric Cancer

Summary

The goal of this observational study is to analyze the impact of different durations of neoadjuvant PD-1 inhibitor combined with chemotherapy on tumor regression and safety in patients with advanced gastric cancer. The main questions it aims to answer are: * Does the duration of neoadjuvant treatment influence tumor regression grading (TRG)? * How does treatment duration affect perioperative safety and clinical outcomes? Participants who have previously undergone neoadjuvant PD-1 inhibitor combined with chemotherapy followed by surgery as part of their routine medical care will have their clinical data retrospectively reviewed and analyzed.

Eligibility

Inclusion Criteria:

* Non-bedridden patients aged 18-90 years;
* Histologically confirmed gastric or gastroesophageal junction adenocarcinoma by biopsy;
* Evaluated as resectable advanced gastric cancer via CT, MRI, or laparoscopic exploration;
* No prior anti-tumor treatments such as chemotherapy, radiotherapy, or immunotherapy;
* No history of other malignancies within the past 5 years;
* Received at least one cycle of PD-1 inhibitor combined with chemotherapy preoperatively, with no restrictions on the specific PD-1 inhibitor or chemotherapeutic agents;
* Underwent radical gastrectomy after neoadjuvant therapy;
* No severe underlying diseases.

Exclusion Criteria:

* Incomplete or inaccessible clinical and pathological data;
* Postoperative pathology confirming non-gastric or non-gastroesophageal junction adenocarcinoma;
* Distant metastases present prior to treatment;
* Concurrent diagnosis of other malignancies.

Conditions2

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