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Patients with Human Papillomavirus-associated Head and Neck Cancer for the Discovery of Predictive Biomarkers to Guide Clinical Intervention

RECRUITINGSponsored by Regina Elena Cancer Institute
Actively Recruiting
SponsorRegina Elena Cancer Institute
Started2024-07-24
Est. completion2026-07-24
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06821243

Summary

Prospective pilot study, non-interventional, of a biological/radiological nature, which involves the collection of tissue samples, and blood from patients suffering from squamous cell carcinoma of the oropharynx OPSCC for detection of HPV-DNA/RNA and immuno-phenotypic analysis of T cells, study of extracellular vesicles, and dosages of cytokines and chemokines involved in the immune response

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Squamous cell carcinomas of the oropharynx (OPSCC) candidates for surgical
* Age \> 18 years
* ECOG performance status \<\_ 2
* Signature of informed consent (to participate in the study and data processing)

Exclusion Criteria:

* Presence of distant metastases at the time of diagnosis
* Previous head and neck cancer

Conditions2

CancerSquamous Cell Carcinoma of Oropharynx

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