Haemodynamics and Ventricular Arrhythmias During Exercise in Patients With Arrhythmogenic Cardiomyopathy

Summary

Patients with definitive and borderline arrhythmogenic cardiomyopathy (ACM) are usually recommended to refrain from high intensity exercise due to an increased risk of malignant arrhythmias. However, little is known about the effects of prolonged, low-to moderate endurance or resistance exercise on the burden of arrhythmias or central haemodynamics. This pilot interventional study assesses the impact of these modes of exercise on the electrophysiological substrate of the right ventricle (RV), measured by mapping of the RV, and central haemodynamics assessed by right heart catheterization. Patients older than 18 years of age with diagnosed borderline and definitive ACM are included with or without implantable cardioverter-defibrillator (ICD).

Eligibility

Inclusion Criteria:

* Age \>18 years of age
* Diagnosis of definitive or borderline arrhythmogenic cardiomyopathy (ACM) with or without implantable cardioverter defibrillator (ICD)

Exclusion Criteria:

* Age \<18 years of age
* Manifest acute heart failure
* Intracardiac shunts
* Pre-existing precapillary pulmonary hypertension
* Clinical suspicion of new coronary artery disease or disease progression
* More than grade II valvular heart disease at resting echocardiography

Conditions2

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