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Sleep TMS for Depression

RECRUITINGN/ASponsored by Stanford University
Actively Recruiting
PhaseN/A
SponsorStanford University
Started2025-05-01
Est. completion2028-05-30
Eligibility
Age18 Years – 65 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06824415

Summary

The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.

Eligibility

Age: 18 Years – 65 YearsHealthy volunteers accepted
Inclusion Criteria:

* Adults ages 18-65 years
* Current Major Depressive Disorder (MDD) diagnosis
* Failed ≥1 antidepressant medication
* Moderate-to-severe depression
* Stable antidepressant medication dose for ≥ 6 weeks prior to enrollment
* Healthy control participants are adults ages 18-65 years without current MDD symptoms, not taking antidepressant or antipsychotic medications, and without major psychiatric, neurological, substance use, medical conditions affecting brain function, or TMS/MRI contraindications.

Exclusion Criteria:

* Intellectual disability
* Significant head injury/neurological disorder
* Pregnancy or postpartum
* TMS/MRI contraindications
* Active substance use/suicidal ideation

Conditions3

DepressionMajor DepressionSleep

Locations1 site

Stanford University
Stanford, California, 94305
Hansong Lee, MS408-909-2203kellerlab@stanford.edu

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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