Involvement of the Immune System in Intrinsic Radiosensitivity

Summary

Radiotherapy is one of the major treatments for cancer. It may be indicated in more than two-thirds of patients, regardless of cancer location or disease stage. The mechanisms of radiotherapy action are numerous: halting tumor proliferation, inducing tumor cell death, triggering anti-tumor immune responses, and ensuring both local and systemic tumor control. As a result, current treatments are highly effective, providing, for instance, a 5-year overall survival rate of about 90%-95% for localized breast and prostate cancers.

Eligibility

Inclusion Criteria:

* Age ≥ 18 years
* Patients who have been treated with radiotherapy
* Absence of toxicity grade 2 or higher
* Patients without psychiatric, sociological, family, or geographical difficulties that could interfere with patient compliance to the protocol or follow-up
* Information and signed informed consent
* Affiliated with social security

Exclusion Criteria:

* Inability to obtain patient consent
* Patient refusing blood sample collection
* Patient deprived of liberty or under legal protection (under guardianship, under curatorship)
* Patients who have experienced radiation-induced toxicity of grade 2 or higher
* Disease progression, relapse
* Patient under State Medical Aid

Conditions2

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