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Impact of PEG Bowel Preparation on Gut Microbiome Composition Recovery

RECRUITINGPhase 1Sponsored by Centre hospitalier de l'Université de Montréal (CHUM)
Actively Recruiting
PhasePhase 1
SponsorCentre hospitalier de l'Université de Montréal (CHUM)
Started2024-12-05
Est. completion2026-09-01
Eligibility
Age18 Years – 70 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06831539

Summary

The main objective is to evaluate the impact of intestinal preparation on the composition, diversity and metabolome of the intestinal microbiota.

Eligibility

Age: 18 Years – 70 YearsHealthy volunteers accepted
Inclusion Criteria:

* Healthy volunteer participant cohort:

  1. \> 18 years of age
  2. The participant has provided documented informed consent for the participation and to complete PEG bowel preparation and return collected stool samples.

Exclusion Criteria:

* An ileus
* Significant gastric retention
* Suspected or established mechanical bowel obstruction
* Inflammatory or infectious gastrointestinal condition
* Neurologic or cognitive impairment that prevents safe swallowing
* Recent history (\<1 year) of cancer that still requires ongoing treatment
* Recent use of antibiotics 1 month prior to participation in the trial
* History of cardiac disease
* History of active renal dysfunction
* Presence of any absolute contraindication to PEG bowel preparation according to manufacturer labeling

Conditions2

CancerHealthy Participants

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