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PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest

RECRUITINGN/ASponsored by Muehlenkreiskliniken, MKK
Actively Recruiting
PhaseN/A
SponsorMuehlenkreiskliniken, MKK
Started2025-06-01
Est. completion2026-06-30
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06836830

Summary

Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Adults \>= 18 years
* non-traumatic OHCA
* mechanical ventilation via airway device

Exclusion Criteria:

* Patients \< 18 years,
* traumatic cause of OHCA,
* no cardiac arrest, withholding of resuscitation (e.g. Do-Not-Resuscitate orders)

Conditions5

CPRCardiac Arrest (CA)Heart DiseasePEEP, OccultVentilation Therapy

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