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The Effect of Discontinuation of Renin Angiotensin System Inhibitors on the Perioperative Myocardial Injury in Adult Patients Undergoing Colorectal Cancer Surgery

RECRUITINGPhase 3Sponsored by Kasr El Aini Hospital
Actively Recruiting
PhasePhase 3
SponsorKasr El Aini Hospital
Started2025-03-01
Est. completion2026-01-01
Eligibility
Age18 Years – 70 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06862115

Summary

The aim of this study is to estimate the effect of discontinuation of RAS inhibitors on myocardial injury in cancer patients undergoing major abdominal surgeries.

Eligibility

Age: 18 Years – 70 YearsHealthy volunteers accepted
Inclusion Criteria:

* Age \> 18 years
* Both sexes
* ASA 2-3
* Chronic hypertensive patients (\> 3 months before surgery) controlled on ACEIs or ARBs or combination therapy containing one of the RAS inhibitors.
* Scheduled for major abdominal cancer surgery (surgery with an expected duration of \> 2 h from the surgical incision and a postoperative hospital stay of least three days).

Exclusion Criteria:

* Patient refusal.
* Recent myocardial infarction (within 3 months).
* Any condition, which in the opinion of the treating clinician, would result in the patient being harmed by the cessation of the ACE-I and/or ARB therapy.
* Emergency surgery

Conditions4

Angiotensin-Converting-Enzyme InhibitorCancerMyocardium; InjuryPerioperative/Postoperative Complications

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