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The Effect of Discontinuation of Renin Angiotensin System Inhibitors on the Perioperative Myocardial Injury in Adult Patients Undergoing Colorectal Cancer Surgery

NOT_RECRUITINGPhase 3Sponsored by Kasr El Aini Hospital
No longer actively recruiting
PhasePhase 3
SponsorKasr El Aini Hospital
Started2025-03-01
Est. completion2026-01-01
Eligibility
Age18 Years – 70 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06862115

Summary

The aim of this study is to estimate the effect of discontinuation of RAS inhibitors on myocardial injury in cancer patients undergoing major abdominal surgeries.

Eligibility

Age: 18 Years – 70 YearsHealthy volunteers accepted
Inclusion Criteria:

* Age \> 18 years
* Both sexes
* ASA 2-3
* Chronic hypertensive patients (\> 3 months before surgery) controlled on ACEIs or ARBs or combination therapy containing one of the RAS inhibitors.
* Scheduled for major abdominal cancer surgery (surgery with an expected duration of \> 2 h from the surgical incision and a postoperative hospital stay of least three days).

Exclusion Criteria:

* Patient refusal.
* Recent myocardial infarction (within 3 months).
* Any condition, which in the opinion of the treating clinician, would result in the patient being harmed by the cessation of the ACE-I and/or ARB therapy.
* Emergency surgery

Conditions4

Angiotensin-Converting-Enzyme InhibitorCancerMyocardium; InjuryPerioperative/Postoperative Complications

Interventions1

ACE-I and/or ARB antihypertensive treatment

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