The Effect of Cardiac Rehabilitation on Oxidative DNA Damage and Inflammation in Patients With Coronary Artery Disease

Summary

The objective of this study was to determine the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), an indicator of oxidative stress, and to demonstrate oxidative DNA damage in cardiac rehabilitation treatment in patients with coronary artery disease. Additionally, proinflammatory cytokines TNFα, IL-1β, and IL-6 levels were measured to evaluate the significance of cardiac rehabilitation treatment in patients with coronary artery disease and to assess the correlation between cytokine levels and 8-OHdG levels.

Eligibility

Inclusion Criteria:

Inclusion Criteria for Patient Volunteers

1. Patients aged 18-65 years with a diagnosis of coronary artery disease and no contraindications to cardiac rehabilitation and exercise testing
2. Patients who will undergo cardiopulmonary exercise testing before cardiac rehabilitation
3. Patients whose cognitive status is sufficient to complete the study and who can cooperate

Inclusion Criteria for Healthy Volunteers

1. 18 years of age or older
2. Not having a chronic disease (such as uncontrolled diabetes mellitus, hypertension, heart and kidney failure)
3. Not taking regular medication

Exclusion Criteria:

Exclusion Criteria for Patient Volunteers

1. Having heart failure
2. Unstable Angina Pectoris
3. Complex ventricular arrhythmia
4. Having a pacemaker
5. Having orthopedic or neurological diseases that prevent exercise
6. Having kidney-liver disease
7. Exercise is contraindicated
8. History of inflammatory diseases
9. Having a history of cancer-immunologic disease

Exclusion Criteria for Healthy Volunteers

1. Having a history of chronic diseases such as diabetes mellitus, hypertension, heart and kidney failure
2. Being on regular medication for the last 6 months
3. being under 18 years of age

Conditions2

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