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The Locus Coeruleus, Norepinephrine and Cognitive Aging

RECRUITINGN/ASponsored by Cornell University
Actively Recruiting
PhaseN/A
SponsorCornell University
Started2025-06-01
Est. completion2026-07-01
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06880510

Summary

The locus coeruleus (LC) has recently been identified as one of the earliest sites of damage in AD with pathological lesions appearing as early as the mid-20s. In this study, the investigators use a variety of techniques including structural MRI, functional MRI, pupillometry, and transcutaneous vagus nerve stimulation to assess the health of the LC and its relation to easily measurable peripheral variables.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* 18+ years of age
* Able to speak and understand English
* Hearing and vision correctable to normal or near-normal
* Willing and able to use a touchscreen
* Willing and able to use a keyboard and mouse
* Willing and able to undergo a MRI scan at the Cornell MRI Facility lasting approximately 90 minutes.

Exclusion Criteria:

* Moderate or severe brain injury
* Serious neurological disorders such as epilepsy
* Recent concussion
* Colorblindness
* Use of street drugs
* Cardiac arrhythmias

Conditions2

Alzheimer DiseaseAlzheimer's Disease

Locations1 site

Cornell University
Ithaca, New York, 14850
Elizabeth Riley, PhD6072532046er482@cornell.edu

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