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Timing of Renal Replacement Therapy Initiation in Tumor Lysis Syndrome

RECRUITINGSponsored by University Hospital, Bordeaux
Actively Recruiting
SponsorUniversity Hospital, Bordeaux
Started2025-07-01
Est. completion2027-07
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06889974

Summary

The TENDERS study aims to evaluate the impact of the timing of renal replacement therapy (RRT) initiation on outcomes in patients with tumor lysis syndrome (TLS) and associated acute kidney injury (AKI). The study will compare early versus delayed RRT initiation, examining the effect on renal function at 30 days post-treatment.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Adults aged ≥18 years.
* Hospitalized in the ICU between January 1, 2013, and December 31, 2023.
* Diagnosed with a hematologic malignancy or solid tumor requiring chemotherapy.
* Diagnosed with TLS based on the presence of two or more biochemical criteria (e.g., hyperkalemia, hyperphosphatemia, hyperuricemia, hypocalcemia) within 3 days before or 7 days after chemotherapy initiation.

Exclusion Criteria:

* Patient or family opposition to data collection for research purposes.
* Incomplete medical records that preclude data extraction.

Conditions2

CancerRenal Replacement Therapy for Acute Kidney Injury in ICU

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