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Evaluation of Plasma Renin Concentrations in Cardiac Surgery

RECRUITINGSponsored by Mayo Clinic
Actively Recruiting
SponsorMayo Clinic
Started2025-04-14
Est. completion2026-04
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06895213

Summary

The purpose of this research is to learn more about how renin (a blood test) is affected by cardiopulmonary bypass, the heart-lung machine used during open heart surgery. Renin is a protein that may be elevated in response to low blood pressure or situations where organs do not receive sufficient oxygen. Renin may potentially be used as an indicator for specific treatments aimed to increase the blood pressure. This study will evaluate blood samples for renin concentration throughout the course of open heart surgery.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Adult persons 18 years of age or greater.
* Scheduled for an elective cardiac surgical procedure involving the use of cardiopulmonary bypass.

Exclusion Criteria:

* Surgery involving heart or lung transplantation or implant of a durable left ventricular assist device.
* Emergency cardiac surgery.
* Established diagnosis of any congenital heart disease.
* End-stage kidney disease receiving kidney replacement therapy before surgery.

Conditions2

Cardiac Surgery With Cardiopulmonary BypassHeart Disease

Locations1 site

Mayo Clinic
Rochester, Minnesota, 55905
Patrick M Wieruszewski, Pharm.D.507-255-5732wieruszewski.patrick@mayo.edu

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