A Pilot Study of Synbiotics in Adults With Depressive Symptoms

Summary

This study aims to explore the efficacy and safety of a synbiotic formula (MQU10) in improving mood and well-being in adults with mild to moderate depressive symptoms.

Eligibility

Inclusion Criteria:

* Individuals aged 18 or above
* Patient Health Questionnaire-9 (PHQ-9) score between 5 to 14
* Literate and can complete the self-report questionnaires
* Able to understand the consent and sign the informed consent form

Exclusion Criteria:

* Current diagnosis of substance abuse or dependence;
* A current or past history of bipolar disorder, manic or hypomanic episodes, schizophrenia, personality disorder, posttraumatic stress disorder (PTSD), intellectual disability, neurodegenerative disorders (e. g, Parkinson's disease) or organic mental disorder
* Requiring immediate psychiatric care (e. g, imminently suicidal subjects) or have attempted suicide in the past 3 months
* Use of antipsychotics, antidepressants or sedatives, unless on a stable dose in the last 4 weeks
* History of severe organ failure, renal failure on dialysis, HIV infection
* Active malignancy within 5 years
* History of major surgery on the gastrointestinal tract, except cholecystectomy and appendectomy in the past 5 years
* Night shift work
* History of antibiotic use within 4 weeks
* History of allergy to probiotics or lactose leading to a severe allergic reaction
* Known pregnancy or lactating

Conditions2

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