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Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use

RECRUITINGPhase 1Sponsored by Trustees of Dartmouth College
Actively Recruiting
PhasePhase 1
SponsorTrustees of Dartmouth College
Started2025-04-13
Est. completion2025-12
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site

Summary

The goal of this clinical trial is to learn if Therabot-CALM (Cannabis, Anxiety, Low Mood) has acceptability among users and could work to improve the symptoms of persons with cannabis use disorder and anxiety and/or depression. The main question it aims to answer is: What is the usability, feasibility, and acceptability of Therabot-CALM in persons with Cannabis Use Disorder and Anxiety and/or Depression? Participants will * Take a screening questionnaire * Participate in two virtual 1-hour interviews to provide feedback on app design and suggest features. * Engage with Therabot-CALM in a 4-week clinical trial and provide feedback on their app experience in a third virtual interview

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Is 18 years or older.
* Meet criteria for current CUD (CUDIT-R\>=12) and MDD (PHQ-9\>=10), and/or GAD (GAD-7\>=10).
* Have reliable access to the internet and a compatible device for Therabot-CALM.
* Have willingness and capacity to provide informed consent and commit to participating in all assessments and interventions during the study.
* Attend the first interview.

Exclusion Criteria:

* Moderate to High risk of STBs as determined by the C-SSRS or baseline questionnaires.
* Current psychosis (as determined by brief psychosis screen).
* Current participation in another digital mental health intervention.

Conditions5

AnxietyCannabis Use DisorderDepressionDepression - Major Depressive DisorderDepression, Anxiety

Locations1 site

46 Centerra Parkway, Suite 300, Office #333S
Lebanon, New Hampshire, 03766
Nicholas C Jacobson, Ph.D.8148630115Nicholas.C.Jacobson@dartmouth.edu

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