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Identification of Specific Molecular Signatures in Pediatric, Adolescent, and Young Adult Rhabdomyosarcoma Through Spatial Proteome Analysis Using Mass Spectrometry

RECRUITINGSponsored by Lille University
Actively Recruiting
SponsorLille University
Started2025-03-13
Est. completion2025-12-31
Eligibility
Age0 Years – 25 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06924463

Summary

This non-interventional study aims to develop spatial proteomics for analyzing small FFPE tumor samples in rhabdomyosarcoma. It will identify molecular signatures linked to tumor regions, subtypes, survival, and treatment resistance, using pre-existing samples and data.

Eligibility

Age: 0 Years – 25 YearsHealthy volunteers accepted
Inclusion Criteria:

* Age between 0 and 25 years at the time of initial diagnosis
* Diagnosis of rhabdomyosarcoma confirmed histologically
* Care at the Oscar Lambret Center between January 2005 and November 2024
* No objection to the re-use of data and biological samples collected as part of care for research activities.

Exclusion Criteria:

* Unavailability of biological sample in FFPE from biopsy and/or surgical specimen for diagnosis at Centre Oscar Lambret;
* Patient under guardianship or trusteeship.

Conditions2

CancerRhabdomyosarcoma

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