Organoid Models of Hepatocellular Carcinoma

Summary

A promising tool to elucidate the molecular characteristics of HCC are patient-derived organoids (PDOs), three-dimensional cultures of cells that self-organise according to tissue-specific patterns and can be used to test the susceptibility of a specific tumour to anticancer agents. In this study, PDOs for HCC will be developed that closely resemble the tumour microenvironment in vivo and mimic the crosstalk of the gut-liver axis to establish a correlation with patient prognosis and test the efficacy of available systemic therapies.

Eligibility

Inclusion Criteria:

* Capacity to express informed consent;
* Age ≥18 years;
* Suspected radiological diagnosis of HCC or diagnosis of HCC with indications for surgical resection.

Exclusion Criteria:

* Age \< 18 years;
* Contraindications to liver biopsy (ascites, platelets\<50,000, INR\>1.7);
* Contraindications to HCC resection surgery;
* Active viral infection;
* Refusal to sign informed consent to participate in the study.

Conditions9

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