Types of Intracellular Bacteria in Atherosclerotic Plaques and Analysis of Risk Factors

Summary

The goal of this iBacAP study is to identify the types of carotid plaques containing intracellular bacteria in patients with atherosclerosis and to look for associated risk factors. The main questions it aims to answer are the type and distribution of intracellular bacteria in patients' plaques, and whether patients with different intracellular bacterial species have a worse prognosis. The researchers will comparatively analyse the presence of intracellular bacteria in the plaques of patients with different types of carotid artery stenosis and how diverse they are, and observe whether the type of intracellular bacteria has an impact on prognosis. Participants will: 1\. all participants will have no intervention, conventional treatment including conditioning and surgery.

Eligibility

Inclusion Criteria:

* All enrolled patients were diagnosed with clear head and neck artery stenosis and a risk event after head and neck revascularization;
* Location of lesion: origin of internal carotid artery, bifurcation of internal and external carotid arteries;
* Patients with symptomatic head and neck artery stenosis and dangerous events after head and neck blood flow reconstruction, and with a degree of stenosis ≥ 70% on non-invasive examination or stenosis ≥ 50% found on angiography;
* Asymptomatic head and neck artery stenosis and risk events after head and neck revascularization, with a degree of stenosis ≥ 70% on non-invasive examination or stenosis ≥ 60% found on angiography;
* Asymptomatic head and neck artery stenosis and dangerous events after head and neck blood flow reconstruction, with a non-invasive examination of stenosis degree less than 70%, but angiography or other examinations indicate that the stenosis lesion is in an unstable state;
* Symptomatic head and neck artery stenosis and risk events after head and neck revascularization, non-invasive examination of head and neck artery stenosis and risk event degree after head and neck revascularization at 50% to 69%

Exclusion Criteria:

* Patients with poor overall condition and intolerance to general anesthesia;
* Patients with mental illness or severe mental illness;
* Severe respiratory system diseases;
* Pregnant and lactating women;
* Participating in another clinical study;
* Patients with advanced tumors or those who are expected to die within one year;

Conditions9

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