Therapeutic Strategies for Type 2 Diabetes Based on Lifestyle Changes: Plant-based Diet and Physical Exercise

Summary

The study evaluates the impact of a strict vegetarian diet combined with regular physical exercise and the use of probiotics on metabolic, inflammatory, and epigenetic parameters in patients with type 2 diabetes. It aims to determine the influence of these interventions on gut microbiota, glycemic control, body composition, insulin resistance, and quality of life.

Eligibility

Inclusion Criteria:

* Have a medical diagnosis of type 2 diabetes for a maximum of 5 years.
* Be omnivorous; Have a Body Mass Index (BMI) ≥ 25 kg/m2 and \< 40 kg/m2;
* Be between the ages of 45 and 70, both genders.
* Women should be in the postmenopausal stage;
* Use no more than three hypoglycemic medications in total;
* Have the availability for a four-week consecutive hospitalization at CSVN.

Exclusion Criteria:

* Be using insulin, anti-obesity medications, antibiotics, and/or probiotic supplements in the 2 months preceding data collection;
* Use of alcohol or tobacco;
* Have limited mobility and a previous diagnosis of cardiopulmonary diseases;
* Report current or previous (within the past two months) diarrhea during screening;
* Have liver or kidney failure and uncontrolled endocrine disorders (hypothyroidism, hypogonadism, and adrenal insufficiency);
* Have eating disorders or have undergone bariatric surgery.

Conditions5

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