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Healthy Volunteers Study

RECRUITINGSponsored by Abramson Cancer Center at Penn Medicine
Actively Recruiting
SponsorAbramson Cancer Center at Penn Medicine
Started2025-04-21
Est. completion2027-01-15
Eligibility
Age30 Years – 50 Years
SexFEMALE
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06962059

Summary

The purpose of this study is to examine the role of the bacterial environments and metabolites in the early detection and prediction of ovarian cancer development. Vaginal swabs and stool samples will be collected from healthy volunteers, or those without a known ovarian cancer diagnosis or genetic ovarian cancer risk. These samples will be compared to samples from participants with increased cancer risk and ovarian cancer diagnoses.

Eligibility

Age: 30 Years – 50 YearsSex: FEMALEHealthy volunteers accepted
Inclusion Criteria:

* has ovaries

Exclusion Criteria:

* genetic mutations which increase risk of ovarian cancer: BRCA1/2, BRIP1, PALB2, Lynch Syndrome (MLH1, MSH2/EPCAM, MSH6) and ATM
* no genetic testing results or unknown genetic status
* prior cancer diagnosis
* prior cancer treatment
* HRT use
* Antibiotic use (1 month prior to providing sample)

Conditions3

CancerGenetic Predisposition to DiseaseOvarian Cancer

Locations1 site

Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104
Susan Domchek, MD855-216-0098PennCancerTrials@emergingmed.com

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