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Test of Target Engagement of Ambiguity Aversion

RECRUITINGN/ASponsored by Northwestern University
Actively Recruiting
PhaseN/A
SponsorNorthwestern University
Started2025-07-07
Est. completion2029-07-01
Eligibility
Age25 Years – 60 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06962527

Summary

The present work aims to test whether a single session intervention alters ambiguity aversion, both in terms of people's decision making and their brain responses to ambiguous choices.

Eligibility

Age: 25 Years – 60 YearsHealthy volunteers accepted
Inclusion Criteria:

1. Ages 25 to 60
2. Right-handed
3. Ability to read and write English
4. Capacity to provide informed consent
5. Intolerance of uncertainty score ≥ -0.5 standard deviation below the mean (31st percentile)

Exclusion Criteria:

1. Personal history of psychosis, mania, or hypomania
2. Personal history of autism spectrum disorder
3. IQ \< 80 as determined by the Wechsler Test of Adult Reading
4. Head injury with greater than 120 seconds loss of consciousness
5. Neurological condition (e.g., epilepsy, Parkinson's, cerebral palsy, history of stroke)
6. Currently pregnant
7. Use of any implanted electrical device (e.g., pacemaker, spinal stimulator, vagal nerve stimulator, Inspire sleep apnea device, etc.).

Conditions5

AnxietyDepressionDepression, AnxietyIntolerance of UncertaintyIntolerance of Uncertainty; Anxiety

Locations1 site

Northwestern University
Chicago, Illinois, 60611
Brent I Rappaport, Ph.D.(312) 585-6603‬decisionmaking@northwestern.edu

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