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Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery

RECRUITINGPhase 3Sponsored by Washington University School of Medicine
Actively Recruiting
PhasePhase 3
SponsorWashington University School of Medicine
Started2026-03-07
Est. completion2027-04-01
Eligibility
Age60 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06969287

Summary

The investigation will establish biological plausibility and infrastructure required for a multisite clinical trial evaluating the re-purposing of fluvoxamine to mitigate postoperative delirium risk in geriatric patients undergoing non-cardiac non-intracranial surgery.

Eligibility

Age: 60 Years+Healthy volunteers accepted
Inclusion Criteria:

* English-speaking
* elective non-cardiac or non-intracranial surgery requiring at least a 2-day hospital length of stay

Exclusion Criteria:

* Received investigational drug within the last 7 weeks
* lack of capacity to provide informed consent
* prior known intolerance or allergy to SSRIs or fluvoxamine
* planned postoperative ventilation
* drug or alcohol dependence
* preoperative use of non-NSAID medications with drug-drug interactions of Class X (Avoid Combination) or D (Consider Therapy Modification)
* risk of serotonin syndrome (St John's Wort, SSRIs, or TCA)

Conditions3

DeliriumHeart DiseaseSurgery--Complications

Locations1 site

Washington University School of Medicine/Barnes-Jewish Hospital
St Louis, Missouri, 63110
Sarah Knarr314-362-2415knarr.sarah@wustl.edu

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