Mechanical Dyssynchrony and Microvascular Dysfunction by SPECT

Summary

The project is aimed at studying the feasibility of mechanical dyssynchrony of the left ventricle of the heart, determined by SPECT (gated MPI), as well as its stress-induced dynamics, in the evaluation of patients with coronary microvascular dysfunction in chronic coronary heart diseasу.

Eligibility

Inclusion Criteria:

* Ischemia with no obstructive coronary arteries (INOCA)
* Obstructive coronary artery disease (CAD)
* Patients without evidence of coronary heart disease

Exclusion Criteria:

* Left ventricular ejection fraction \<55% according to echocardiography;
* History of myocardial infarction/revascularization;
* hypertension: systolic blood pressure \>180 mm Hg. Art., diastolic BP\>110 mm Hg. Art.;
* systolic arterial hypotension \<80 mm Hg. Art.;
* atrial fibrillation;
* AV blockade of the III degree; sick sinus syndrome;
* massive pulmonary embolism (PE) with a high degree of pulmonary hypertension;
* the presence of significant valvular pathology (mitral insufficiency ≥ 3 degrees, aortic insufficiency ≥ 3 degrees, tricuspid regurgitation ≥ 3 degrees).
* severe course of bronchial asthma, chronic obstructive pulmonary disease;
* decompensated type 2 diabetes,
* severe liver or kidney failure (glomerular filtration rate \<50 ml/min/1.73 m3 (CKD-EPI),
* morbid obesity (body mass index \>45);
* history of myocarditis
* indications of poor drug tolerance;
* oncological diseases;
* chronic alcoholism, mental disorders;
* other severe comorbidity,
* refusal to participate in the study.

Conditions4

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