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A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity

NOT_RECRUITINGPhase 3Sponsored by Eli Lilly and Company
No longer actively recruiting
PhasePhase 3
SponsorEli Lilly and Company
Started2025-05-15
Est. completion2027-01
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations35 sites
View on ClinicalTrials.gov →

NCT06972459

Summary

The main purpose of this study is to see how orforglipron, compared with placebo, helps reduce body weight in participants with obesity or with overweight and at least one other related health condition (excluding type 2 diabetes). This trial is part of the master protocol study J2A-MC-GZPO (NCT06993792). Participation in the study will last about 18 months.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Have body mass index (BMI) ≥30 kilograms per square meter (kg/m2) or BMI ≥25.0 kg/m2 and at least 1 of the following weight-related comorbidities at screening:

  * hypertension
  * dyslipidemia
  * obstructive sleep apnea, or
  * cardiovascular disease
* Have a history of at least one unsuccessful dietary effort to lose body weight

Exclusion Criteria:

* Have type 1 diabetes, type 2 diabetes, or any other types of diabetes
* Have an unstable body weight within 90 days prior to screening
* Have New York Heart Association functional classification IV congestive heart failure or an acute cardiovascular condition within 90 days prior to screening
* Have acute or chronic hepatitis or pancreatitis
* Are taking other medications or alternative remedies to manage weight loss

Conditions3

DiabetesObesityOverweight

Interventions1

Orforglipron

Locations35 sites

Clinical Research Institute of Arizona (CRI) - Sun City West
Sun City West, Arizona, 85375
Jalal Abbas
Novak Clinical Research - Tucson - North La Cholla Boulevard
Tucson, Arizona, 85741
Thili Kulatilake
Norcal Endocrinology & Internal Medicine
San Ramon, California, 94583
Yshay Shlesinger
Southern California Clinical Research
Santa Ana, California, 92701
Wayne Ho
Care Access - Thousand Oaks
Thousand Oaks, California, 91360
Irving Loh

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