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A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes

RECRUITINGPhase 3Sponsored by Eli Lilly and Company
Actively Recruiting
PhasePhase 3
SponsorEli Lilly and Company
Started2025-05-19
Est. completion2027-01
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations32 sites
View on ClinicalTrials.gov →

NCT06972472

Summary

The main purpose of this study is to see how orforglipron, compared with placebo, helps improve glycemic control in participants with obesity or with overweight and type 2 diabetes. This trial is part of the master protocol study J2A-MC-GZPO. Participation in the study will last about 18 months.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Have body mass index (BMI) ≥25 kilograms per square meter (kg/m2) at screening
* Have type 2 diabetes
* Have hemoglobin A1c (HbA1c) ≥7% and ≤10% at screening
* Have a history of at least one unsuccessful dietary effort to lose body weight

Exclusion Criteria:

* Have type 1 diabetes
* Have an unstable body weight within 90 days prior to screening
* Have New York Heart Association functional classification IV congestive heart failure or an acute cardiovascular condition within 90 days prior to screening
* Have acute or chronic hepatitis or pancreatitis
* Are taking other medications or alternative remedies to manage weight loss

Conditions4

DiabetesObesityOverweightType 2 Diabetes

Locations32 sites

Clinical Research Institute of Arizona (CRI) - Sun City West
Sun City West, Arizona, 85375
Jalal Abbas
Novak Clinical Research - Tucson - North La Cholla Boulevard
Tucson, Arizona, 85741
Thili Kulatilake
Norcal Endocrinology & Internal Medicine
San Ramon, California, 94583
Yshay Shlesinger
Southern California Clinical Research
Santa Ana, California, 92701
Wayne Ho
Care Access - Thousand Oaks
Thousand Oaks, California, 91360
Irving Loh

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