Urinary Microbiome Differences in Bladder Cancer, Benign Urinary Diseases and Healthy Counterparts in Adult Male Population

Summary

The study aims to investigate alterations in the bladder microbiome in adult men with bladder cancer, healthy men, and men with benign urinary disease

Eligibility

Inclusion Criteria (Bladder Cancer Patients):

* Diagnosis of bladder cancer
* Negative urine culture
* Histological confirmation of urothelial carcinoma
* Patients undergoing radical cystectomy

Exclusion Criteria:

* Presence of other neoplasias
* History of previous BCG therapy
* Use of indwelling catheter
* Active antibiotic treatment with two months prior to participation
* History of sexual transmitted diseases
* Presence of chronic intestinal inflammation
* Previous neoadyuvant therapy

Inclusion Criteria Controls No-Pathologic/Healthy):

\- Controls will be collected from men within the specified age range. Eligible controls may be drawn from the institution's personnel attending the occupational medicine department or in service in the Institute.

Exclusion Criteria:

* Diabetes
* Chronic Kidney Disease
* Cardiac disease
* Hepatic disease

Inclusion Criteria(Benign Urinary Disease)

-To ensure that alterations in the microbiome observed in bladder cancer patients are unique to this condition, an additional group with benign urinary diseases will be included in the analysis. This group will encompass individuals with renal cysts, benign prostatic obstruction, ureteropelvic or ureteral obstruction undergoing surgical therapy.

Exclusion Criteria:

* NA

Conditions2

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